Meredith Setser's work features large installations composed primarily of handmade and industrial felts printed with traditional processes, such as etching, relief, and screen printing. The installations reference landscape and architectural phenomena, such as grottos and cave formations, and also incorporate debris and plants. Relationships between humans and animals and the environment are addressed in the work, along with ideas pertaining to ritual, religion, and ecological concerns.

Setser is an assistant professor of printmaking at Herron School of Art and Design in Indianapolis. Along with printmaking, she teaches felt making workshops at venues throughout the United States. Her work has been included in numerous national and international juried exhibitions, most recently including the Qijang International Print Exhibition in China.